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Article

[KIT receptor in testicular seminoma].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie - 1 Feb 2005

Paule Bernard

Abstract excerpt

KIT receptor expression is observed in the majority of seminomas. Activation of KIT tyrosine kinase due to somatic mutations has been demonstrated. Mutations of the c-kit gene in testicular seminomas are located in exon 17. Inhibitors of KIT tyrosine kinase activity can have a therapeutic role, particularly in seminomas with a c-kit mutation sensitive to imatinib mesylate. A clinical trial plans to examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15822404

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[KIT receptor in testicular seminoma].PMID 15822404Read ↗

KIT mutations are common in testicular seminomas.Semantic proximity Read ↗

Alterations of the c-kit gene in testicular germ cell tumors.Semantic proximity Read ↗

KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literatureSemantic proximity Read ↗

Amplification and Overexpression of the <i>KIT</i> Gene Is Associated with Progression in the Seminoma Subtype of Testicular Germ Cell Tumors of Adolescents and AdultsSemantic proximity Read ↗

Mutations and protein expression of KIT and PDGFRA genes in ipsilateral testicular seminomas: an immunohistochemical and molecular genetic study.Semantic proximity Read ↗

KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors.Semantic proximity Read ↗

KIT gene mutation and amplification in dysgerminoma of the ovary.Semantic proximity Read ↗

Expression of KIT and epidermal growth factor receptor in chemotherapy refractory non-seminomatous germ-cell tumors.Semantic proximity Read ↗

Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.Semantic proximity Read ↗

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