Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of KIT and epidermal growth factor receptor in chemotherapy refractory non-seminomatous germ-cell tumors.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2003

Madani A, Kemmer K, Sweeney C, Corless C, Ulbright T, Heinrich M, Einhorn L

Abstract excerpt

BACKGROUND: The majority of patients with germ-cell tumors (GCTs) are curable with standard therapy. The molecular differences between curable and incurable disease are unknown. We have studied the expression of KIT and the epidermal growth factor receptor (EGFR) to determine their incidence in chemorefractory disease. PATIENTS AND METHODS: We retrospectively analyzed 23 patients with chemorefractory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Neoplasm
Share to Germinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Neoplasm Recurrence, Local

Share to Neoplasm Staging

Share to Proto-Oncogene Proteins c-kit

Share to Teratoma

Share to Testicular Neoplasms

Source

Identifiers

PMID: 12796025
DOI: 10.1093/annonc/mdg244

Genes

KIT
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of KIT and epidermal growth factor receptor in chemotherapy refractory non-seminomatous germ-cell tumors.PMID 12796025Read ↗

Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors.Semantic proximity Read ↗

RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors.Semantic proximity Read ↗

KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literatureSemantic proximity Read ↗

Targeted therapies for patients with germ cell tumors.Semantic proximity Read ↗

KIT mutations are common in testicular seminomas.Semantic proximity Read ↗

Frequent EGFR expression/EGFR amplification and lack of activating mutation in testicular choriocarcinoma.Semantic proximity Read ↗

Alterations of the c-kit gene in testicular germ cell tumors.Semantic proximity Read ↗

Amplification and Overexpression of the <i>KIT</i> Gene Is Associated with Progression in the Seminoma Subtype of Testicular Germ Cell Tumors of Adolescents and AdultsSemantic proximity Read ↗

Detection of c-kit exons 11- and 17-activating mutations in testicular seminomas by high-resolution melting amplicon analysisSemantic proximity Read ↗

c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma.Semantic proximity Read ↗

Phase II trial of nivolumab monotherapy and biomarker screening in patients with chemo‐refractory germ cell tumorsSemantic proximity Read ↗

Role of P53 and MDM2 in Treatment Response of Human Germ Cell TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.