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Article

KIT mutations are common in testicular seminomas.

The American journal of pathology - 1 Jan 2004

Kemmer Kathleen, Corless Christopher L, Fletcher Jonathan A, McGreevey Laura, Haley Andrea, Griffith Diana, Cummings Oscar W, Wait Cecily, Town Ajia, Heinrich Michael C

Abstract excerpt

Expression of KIT tyrosine kinase is critical for normal germ cell development and is observed in the majority of seminomas. Activating mutations in KIT are common in gastrointestinal stromal tumors and mastocytosis. In this study we examined the frequency and spectrum of KIT mutations in 54 testicular seminomas, 1 ovarian dysgerminoma and 37 non-seminomatous germ cell tumors (NSGCT). Fourteen seminomas (25.9%)...

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Source

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Identifiers

PMID: 14695343
DOI: 10.1016/S0002-9440(10)63120-3
PMCID: PMC1602213

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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KIT mutations are common in testicular seminomas.PMID 14695343Read ↗

Alterations of the c-kit gene in testicular germ cell tumors.Semantic proximity Read ↗

KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors.Semantic proximity Read ↗

c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma.Semantic proximity Read ↗

A c-KIT codon 816 mutation, D816H, in the testicular germ cell tumor: case report of a Japanese patient with bilateral testicular seminomas.Semantic proximity Read ↗

Primary mediastinal seminomas: evidence of single and multiple KIT mutations.Semantic proximity Read ↗

Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.Semantic proximity Read ↗

Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.Semantic proximity Read ↗

KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literatureSemantic proximity Read ↗

RAS/MAPK Pathway Driver Alterations Are Significantly Associated With Oncogenic KIT Mutations in Germ-cell Tumors.Semantic proximity Read ↗

The novel KIT exon 11 germline mutation K558N is associated with gastrointestinal stromal tumor, mastocytosis, and seminoma development.Semantic proximity Read ↗

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