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An <i>In Silico</i> Evaluation of Deleterious Nonsynonymous Single Nucleotide Polymorphisms in the <i>ErbB3</i> Oncogene

26 Apr 2013

Abstract excerpt

ErbB3 is a significant oncogenic target that is involved in the development of numerous malignancies. In the present in silico study, we evaluated the structural and functional impact of single nucleotide polymorphisms (SNPs) on the ErbB3 gene. The nonsynonymous SNPs (nsSNPs) are known to be deleterious or disease-causing variations because they alter protein sequence, structure, and function. Out of a total 531...

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PMID: 23741632
DOI: 10.1089/biores.2013.0007

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