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Article

Epistasis analysis with global transcriptional phenotypes.

Nature genetics - 1 May 2005

Van Driessche Nancy, Demsar Janez, Booth Ezgi O, Hill Paul, Juvan Peter, Zupan Blaz, Kuspa Adam, Shaulsky Gad

Abstract excerpt

Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a variety of experimental expertise and so is unsuitable for genome-scale analysis. Here we used microarray profiles of mutants as phenotypes for epistasis analysis. Considering genes that regulate activity of...

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PMID: 15821735
DOI: 10.1038/ng1545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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