Article
Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity.
The Journal of clinical endocrinology and metabolism - 1 Jan 2005
Andersen Kirstine L, Echwald Søren M, Larsen Lesli H, Hamid Yasmin H, Glümer Charlotte, Jørgensen Torben, Borch-Johnsen Knut, Andersen Teis, Sørensen Thorkild I A, Hansen Torben, Pedersen Oluf
Abstract excerpt
Obesity is a prominent feature of the Bardet-Biedl syndrome (BBS), one subset of which, BBS6, is due to mutations in the chaperonin-like gene termed the McKusick-Kaufman syndrome (MKKS) gene. We tested whether variation in MKKS contributes to common and probably polygenic forms of obesity by performing mutation analysis of the coding region in 60 Danish white men with juvenile-onset obesity. Five variants were...
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