Article
Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan.
The FEBS journal - 1 Apr 2005
André Sabine, Kojima Shuji, Prahl Ingo, Lensch Martin, Unverzagt Carlo, Gabius Hans-Joachim
Abstract excerpt
A series of enzymatic substitutions modifies the basic structure of complex-type biantennary N-glycans. Among them, a beta1,2-linked N-acetylglucosamine residue is introduced to the central mannose moiety of the core-fucosylated oligosaccharide by N-acetylglucosaminyltransferase VII. This so-called LEC14 epitope can undergo galactosylation at the beta1,2-linked N-acetylglucosamine residue. Guided by the...
Topics
- Agglutinins
- Animals
- Carbohydrate Sequence
- Cell Line
- Cell Line, Tumor
- Epitopes
- Flow Cytometry
- Fucose
- Glycoproteins
- Glycosylation
- Humans
- Lectins
- Mice
- Molecular Sequence Data
- Mutation
- Polysaccharides
- Protein Binding
- Tissue Distribution