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Article

Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase--a way to new glycodrugs and materials.

Glycobiology - 1 May 2009

Bojarová Pavla, Krenek Karel, Wetjen Katharina, Adamiak Kathrin, Pelantová Helena, Bezouska Karel, Elling Lothar, Kren Vladimír

Abstract excerpt

Human placental beta1,4-galactosyltransferase-I (EC 2.4.1.38) transfers the galactosyl moiety from UDP-Gal to various GlcNAc or Glc acceptors in vivo. Here, we describe the construction of its Y284L mutant as a His(6)propeptide-catbeta4GalT1 construct, in which the Gal-transferase activity was totally abolished in favor of its GalNAc-transferase activity. We used this mutant in the synthesis of three mono- and...

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Identifiers

PMID: 19179461
DOI: 10.1093/glycob/cwp010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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