Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.

Experimental cell research - 1 May 2005

Vetterkind Susanne, Illenberger Susanne, Kubicek Jan, Boosen Meike, Appel Sarah, Naim Hassan Y, Scheidtmann Karl-Heinz, Preuss Ute

Abstract excerpt

Prostate apoptosis response-4 (Par-4) is a 38-kDa protein originally identified as a gene product upregulated in prostate cancer cells undergoing apoptosis. Cell death mediated by Par-4 and its interaction partner DAP like kinase (Dlk) is characterized by dramatic changes of the cytoskeleton. To uncover the role of the cytoskeleton in Par-4/Dlk-mediated apoptosis, we analyzed Par-4 for a direct association with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Actins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apoptosis Regulatory Proteins

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Cardiac Myosins

Share to Death-Associated Protein Kinases

Share to MAP Kinase Kinase Kinases

Share to Myosin Light Chains

Source

Identifiers

PMID: 15817164
DOI: 10.1016/j.yexcr.2005.01.012

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.PMID 15817164Read ↗

Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymoreSemantic proximity Read ↗

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.Semantic proximity Read ↗

Par-4 links dopamine signaling and depression.Semantic proximity Read ↗

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells.Semantic proximity Read ↗

Apoptosis and tumor resistance conferred by Par-4Semantic proximity Read ↗

Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia.Semantic proximity Read ↗

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1Semantic proximity Read ↗

Mechanisms of apoptosis by the tumor suppressor Par-4.Semantic proximity Read ↗

Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis.Semantic proximity Read ↗

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cellsSemantic proximity Read ↗

Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 PromoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.