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Article

Mechanisms of apoptosis by the tumor suppressor Par-4.

Journal of cellular physiology - 1 Dec 2012

Hebbar Nikhil, Wang Chi, Rangnekar Vivek M

Abstract excerpt

Par-4 is a pro-apoptotic, tumor suppressor protein that induces apoptosis selectively in cancer cells. Endoplasmic reticulum-stress and higher levels of protein kinase A in tumor cells confer the coveted feature of cancer selective response to extracellular and intracellular Par-4, respectively. Recent studies have shown that systemic Par-4 confers resistance to tumor growth in mice, and that tumor-resistance is...

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Identifiers

PMID: 22552839
DOI: 10.1002/jcp.24098
PMCID: PMC3414654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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