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Article

Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 Promoter

1 May 2003

Abstract excerpt

Elevated expression levels of the bcl-2 proto-oncogene have been extensively correlated with the appearance of androgen independence in prostate cancer. Although bcl-2 was first cloned as the t(14:18) translocation breakpoint from human follicular B cell lymphoma, the mechanism of overexpression of bcl-2 is largely undefined for advanced prostate cancer because there are no gross alterations in the gene...

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PMID: 12644474
DOI: 10.1074/jbc.m205865200

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Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 PromoterPMID 12644474Read ↗

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