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Article

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells.

Molecular and cellular biology - 1 Aug 2003

El-Guendy Nadia, Zhao Yanming, Gurumurthy Sushma, Burikhanov Ravshan, Rangnekar Vivek M

Abstract excerpt

Recent studies indicated that the leucine zipper domain protein Par-4 induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. However, the intracellular localization or functional domains of Par-4 involved in apoptosis remained unknown. In the present study, structure-function analysis indicated that inhibition of...

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Identifiers

PMID: 12897127
DOI: 10.1128/MCB.23.16.5516-5525.2003
PMCID: PMC166354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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