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Article

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice.

Neurobiology of aging - 1 Mar 2008

Machová E, Jakubík J, Michal P, Oksman M, Iivonen H, Tanila H, Dolezal V

Abstract excerpt

We assessed the integrity of cholinergic neurotransmission in parietal cortex of young adult (7 months) and aged (17 months) transgenic APPswe/PS1dE9 female mice compared to littermate controls. Choline acetyltransferase and acetylcholinesterase activity declined age-dependently in both genotypes, whereas both age- and genotype-dependent decline was found in butyrylcholinesterase activity, vesicular acetylcholine...

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Source

Identifiers

PMID: 17140703
DOI: 10.1016/j.neurobiolaging.2006.10.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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