Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens.

doi:10.1007/s00406-004-0545-7

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Article

Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens.

European archives of psychiatry and clinical neuroscience - 1 Apr 2005

Tadic Andre, Dahmen Norbert, Szegedi Armin, Rujescu Dan, Giegling Ina, Koller Gabriele, Anghelescu Ion, Fehr Christoph, Klawe Christoph, Preuss Ullrich W, Sander Thomas, Toliat Mohammad R, Singer Peter, Bondy Brigitta, Soyka Michael

Abstract excerpt

OBJECTIVE: Ethanol-inhibited glutamatergic neurotransmission has been shown to mediate pathophysiological mechanisms in the development of alcoholism, including withdrawal symptoms. NMDA-receptor 2B (NR2B) is a subunit that confers a high sensitivity to ethanol-induced inhibition. Previously we had reported a lack of association between the single nucleotide polymorphism (SNP) rs1806201 in the NR2B gene (GRIN2B)...

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PMID: 15812607
DOI: 10.1007/s00406-004-0545-7

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