Article
Polymorphisms in the N-methyl-D-aspartate receptor 1 and 2B subunits are associated with alcoholism-related traits.
Biological psychiatry - 1 Nov 2003
Wernicke Catrin, Samochowiec Jerzy, Schmidt Lutz G, Winterer Georg, Smolka Michael, Kucharska-Mazur Jolanta, Horodnicki Jan, Gallinat Jürgen, Rommelspacher Hans
Abstract excerpt
BACKGROUND: This study examined the hypothesis that allelic variants of the ionotropic glutamatergic N-methyl-D-aspartate receptor (NMDAR) are associated with vulnerability to alcoholism and some related traits. METHODS: We investigated the silent G2108A and C2664T polymorphisms of the NMDAR1 and the NMDAR2B genes, respectively. The case control study included 367 alcoholic and 335 control subjects of German...
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