Article
Key roles of histone methyltransferase and demethylase in leukemogenesis.
Journal of cellular biochemistry - 1 Feb 2011
Yoshimi Akihide, Kurokawa Mineo
Abstract excerpt
A growing body of evidence has underlined the involvement of histone methyltransferases and demethylases in leukemia development. These findings can be roughly classified into two categories according to their association with leukemia. On the one hand, these histone modifiers are recruited to DNA by specific affinities of aberrantly expressed transcription factors or fusion proteins, and induce chromatin...
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