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Article

Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2008

Kubli Dieter A, Quinsay Melissa N, Huang Chengqun, Lee Youngil, Gustafsson Asa B

Abstract excerpt

Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (Bnip3) is a member of the Bcl-2 homology domain 3-only subfamily of proapoptotic Bcl-2 proteins and is associated with cell death in the myocardium. In this study, we investigated the potential mechanism(s) by which Bnip3 activity is regulated. We found that Bnip3 forms a DTT-sensitive homodimer that increased after myocardial ischemia-reperfusion (I/R)....

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Identifiers

PMID: 18790835
DOI: 10.1152/ajpheart.00552.2008
PMCID: PMC2614576

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