Article
A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis.
Genes & development - 15 Sept 2005
Yoshikawa Manabu, Peragine Angela, Park Mee Yeon, Poethig R Scott
Abstract excerpt
The Arabidopsis genes, TAS2 and TAS1a, produce structurally similar noncoding transcripts that are transformed into short (21-nucleotide [nt]) and long (24-nt) siRNAs by RNA silencing pathways. Some of these short siRNAs direct the cleavage of protein-coding transcripts, and thus function as trans-acting siRNAs (ta-siRNAs). Using genetic analysis, we defined the pathway by which ta-siRNAs and other short siRNAs...
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