The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.

doi:10.18632/oncotarget.2528

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Article

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.

Oncotarget - 15 Nov 2014

Ringer Lymor, Sirajuddin Paul, Tricoli Lucas, Waye Sarah, Choudhry Muhammad Umer, Parasido Erika, Sivakumar Angiela, Heckler Mary, Naeem Aisha, Abdelgawad Iman, Liu Xuefeng, Feldman Adam S, Lee Richard J, Wu Chin-Lee, Yenugonda Venkata, Kallakury Bhaskar, Dritschilo Anatoly, Lynch John, Schlegel Richard, Rodriguez Olga, Pestell Richard G, Avantaggiati Maria Laura, Albanese Chris

Abstract excerpt

The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the p53 pathway is considered a key determinant of anti-tumor responses. p53 can also promote autophagy, however the role of p53-dependent autophagy in chemosensitivity is poorly understood. VMY-1-103 (VMY), a...

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PMID: 25296977
DOI: 10.18632/oncotarget.2528
PMCID: PMC4279402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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