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Article

Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy

8 Jun 2009

Abstract excerpt

Platinum-based drugs that induce DNA damage are commonly used first-line chemotherapy agents for testicular, bladder, head and neck, lung, esophageal, stomach, and ovarian cancers. The inherent resistance of tumors to DNA damage often limits the therapeutic efficacy of these agents, such as cisplatin. An enhanced DNA repair and telomere maintenance response by the Mre11/Rad50/Nbs1 (MRN) complex is critical in...

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PMID: 19487811
DOI: 10.1172/jci33816

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