Article
Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN.
AIDS (London, England) - 24 Mar 2005
Puissant Bénédicte, Roubinet Francis, Dellacasagrande Jérôme, Massip Patrice, Abbal Michel, Pasquier Christophe, Izopet Jacques, Blancher Antoine
Abstract excerpt
We explored the impact of human ABO glycosyltransferase and Lewis and secretor fucosyltransferase polymorphisms in HIV infection. We found that, compared with healthy blood donors, HIV-infected patients display a significant decrease in Le(a-b+) phenotype frequencies. We showed that HIV binding on DC-SIGN-transduced Jurkat cells was inhibited by fucosyl bovine serum albumin. Our results suggest a slight...
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