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Article

Genotypic heterogeneity among Lewis negative individuals.

Biochemical and biophysical research communications - 29 Oct 1993

Elmgren A, Rydberg L, Larson G

Abstract excerpt

We have identified a C to T mutation at nucleotide No 314 in the coding region of the human alpha (1,3/1,4) fucosyltransferase III (FT-III) gene held responsible for synthesis of Lewis a and b antigens. The mutation gives rise to an additional cleavage site for restriction enzyme NlaIII and was found in both alleles in 5 of 18 Lewis negative but in none of 22 Lewis positive individuals. Heterozygous individuals...

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Identifiers

PMID: 8240322
DOI: 10.1006/bbrc.1993.2280

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