Article
Genotypic heterogeneity among Lewis negative individuals.
Biochemical and biophysical research communications - 29 Oct 1993
Elmgren A, Rydberg L, Larson G
Abstract excerpt
We have identified a C to T mutation at nucleotide No 314 in the coding region of the human alpha (1,3/1,4) fucosyltransferase III (FT-III) gene held responsible for synthesis of Lewis a and b antigens. The mutation gives rise to an additional cleavage site for restriction enzyme NlaIII and was f...
Topics
- Amino Acid Sequence
- Base Sequence
- Carbohydrate Sequence
- DNA
- DNA Primers
- Fucosyltransferases
- Genotype
- Heterozygote
- Humans
- Lewis Blood Group Antigens
- Methionine
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Restriction Mapping
- Threonine