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Article

Human noroviruses recognize sialyl Lewis x neoglycoprotein

3 Dec 2008

Abstract excerpt

The carbohydrate binding characteristics of a norovirus GII.3 (Chron1) and a GII.4 (Dijon) strain were investigated using virus-like particles (VLPs) and saliva samples from 81 individuals genotyped for FUT2 (secretor) and FUT3 (Lewis) and phenotyped for ABO and Lewis blood groups. The two VLPs showed a typical secretor-gene-dependent binding and bound significantly stronger to saliva from A, B, and AB than from...

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PMID: 19054801
DOI: 10.1093/glycob/cwn139

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