Article
Molecular mechanisms of Lewis antigen expression.
Legal medicine (Tokyo, Japan) - 1 Jul 2005
Soejima Mikiko, Koda Yoshiro
Abstract excerpt
Lewis antigens comprise type 1 (Lewis a, Lewis b) and type 2 (Lewis X, Lewis Y) carbohydrates. Lewis X and Lewis Y are regarded as tumor-associated markers, and some of these antigens and their derivatives interact with selectins, mediating cell-to-cell adhesion. In addition, Lewis b on the gastric epithelial surface has been identified as an acceptor for attachment of Helicobacter pylori. In this review, we...
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