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Article

Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.

Human pathology - 1 Jun 2002

Soilleux Elizabeth J, Morris Lesley S, Rushbrook Simon, Lee Benhur, Coleman Nicholas

Abstract excerpt

DC-SIGNR is a human immunodeficiency virus (HIV)-binding C-type lectin that is expressed on endothelium in the hepatic sinusoids, lymph node sinuses and placenta. Like closely related DC-SIGN, DC-SIGNR can bind both ICAM-3 and HIV and can potentiate HIV infection of T lymphocytes in trans. In the...

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Source

Identifiers

PMID: 12152166
DOI: 10.1053/hupa.2002.124036

Genes

CD4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12152166-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.PMID 12152166Read ↗

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West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.Semantic proximity Read ↗

Human lectins and their roles in viral infections.Semantic proximity Read ↗

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DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable FunctionsSemantic proximity Read ↗

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HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).Semantic proximity Read ↗

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