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Article

Rare mutations at codon 103 of HIV-1 reverse transcriptase can confer resistance to non-nucleoside reverse transcriptase inhibitors.

AIDS (London, England) - 24 Mar 2005

Harrigan P Richard, Mo Theresa, Wynhoven Brian, Hirsch Jennifer, Brumme Zabrina, McKenna Paula, Pattery Theresa, Vingerhoets Johan, Bacheler Lee T

Abstract excerpt

BACKGROUND: The K103N mutation in HIV-1 reverse transcriptase (RT) confers high-level resistance to current non-nucleoside reverse transcriptase inhibitors (NNRTI). The prevalence and resistance profile of HIV-1 with other substitutions at RT codon 103 is less well documented. METHODS: K103 substitutions among over 70,000 clinical samples submitted for routine antiretroviral resistance testing at two independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15802972
DOI: 10.1097/01.aids.0000163930.68907.37

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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