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Article

Mutations other than 103N in human immunodeficiency virus type 1 reverse transcriptase (RT) emerge from K103R polymorphism under non-nucleoside RT inhibitor pressure.

Virology - 20 Jan 2006

Gatanaga Hiroyuki, Hachiya Atsuko, Kimura Satoshi, Oka Shinichi

Abstract excerpt

K103N mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) confers high-level resistance against non-nucleoside RT inhibitors (NNRTIs) and it easily occurs partly because it arises by a single nucleotide substitution from wild-type K103. There are polymorphisms at codon 103 of HIV-1 RT. We found K103R polymorphic mutation in 3.3% of treatment-naive HIV-1-infected patients. R103N does...

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Identifiers

PMID: 16219331
DOI: 10.1016/j.virol.2005.09.005

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