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Article

Application of an allele-specific PCR to clinical HIV genotyping samples detects additional K103N mutations in both therapy naïve and experienced patients.

Journal of medical virology - 1 Dec 2009

Carr Jillian M, Green Tara, Shaw David, Daly Lyndal, Hart Wendy, Ratcliff Rodney, Higgins Geoffrey, Burrell Christopher J, Li Peng, Qiao Ming

Abstract excerpt

Low-level drug resistance is not detected by routine consensus sequence genotype analysis (CSA) but low levels of specific mutations, such as the non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutation K103N, can be quantitated by allele-specific PCR (ASP). This study has applied an ASP to quantitate low-level K103N in patients presenting for clinical HIV genotyping and assess the correlation...

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Identifiers

PMID: 19856473
DOI: 10.1002/jmv.21628

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Application of an allele-specific PCR to clinical HIV genotyping samples detects additional K103N mutations in both therapy naïve and experienced patients.PMID 19856473Read ↗

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