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Article

Sit4 phosphatase is functionally linked to the ubiquitin-proteasome system.

Genetics - 1 Aug 2003

Singer Thorsten, Haefner Stefan, Hoffmann Michael, Fischer Michael, Ilyina Julia, Hilt Wolfgang

Abstract excerpt

Using a synthetic lethality screen we found that the Sit4 phosphatase is functionally linked to the ubiquitin-proteasome system. Yeast cells harboring sit4 mutations and an impaired proteasome (due to pre1-1 pre4-1 mutations) exhibited defective growth on minimal medium. Nearly identical synthetic effects were found when sit4 mutations were combined with defects of the Rad6/Ubc2- and Cdc34/Ubc3-dependent...

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Source

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Identifiers

PMID: 12930741
DOI: 10.1093/genetics/164.4.1305
PMCID: PMC1462641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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