Article
Increased levels of β-catenin, LEF-1, and HPA-1 correlate with poor prognosis for acral melanoma with negative BRAF and NRAS mutation in BRAF exons 11 and 15 and NRAS exons 1 and 2.
DNA and cell biology - 1 Jan 2015
Xu Sanxiong, Yang Zuozhang, Zhang Jinyu, Jiang Yongxin, Chen Yongbin, Li Hongjun, Liu Xuefeng, Xu Da, Chen Yanjin, Yang Yihao, Zhang Ya, Li Dongxu, Xia Junfeng
Abstract excerpt
To determine the expression of β-catenin, lymphoid enhancer-binding protein-1 (LEF-1), and heparanase-1 (HPA-1) and to evaluate these proteins' potential prognostic values in malignant acral melanoma without mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2, specimens from 90 patients with wild-type BRAF and NRAS were assessed and analyzed by immunohistochemistry and western blotting. The positive...
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