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Article

Telomere dysfunction and the initiation of genome instability.

Nature reviews. Cancer - 1 Aug 2003

Feldser David M, Hackett Jennifer A, Greider Carol W

Abstract excerpt

Tumour growth is an evolutionary process that is characterized by the selection of clonal populations of cells that acquire distinct genetic changes. Many cancer therapies aim to exploit the specific changes that occur in cancer cells, but understanding the underlying mechanisms of genomic instability that cause these mutations could lead to more effective therapies. If common mechanisms exist for initiating...

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PMID: 12894250
DOI: 10.1038/nrc1142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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