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Article

Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.

The Journal of biological chemistry - 10 Jun 2005

Chubykin Alexander A, Liu Xinran, Comoletti Davide, Tsigelny Igor, Taylor Palmer, Südhof Thomas C

Abstract excerpt

To study synapse formation by neuroligins, we co-cultured hippocampal neurons with COS cells expressing wild type and mutant neuroligins. The large size of COS cells makes it possible to test the effect of neuroligins presented over an extended surface area. We found that a uniform lawn of wild type neuroligins displayed on the cell surface triggers the formation of hundreds of uniformly sized, individual...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15797875
DOI: 10.1074/jbc.M410723200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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