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Article

Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

The Journal of biological chemistry - 3 Jun 2005

Yamazaki Tomomi, Sasaki Eriko, Kakinuma Chihaya, Yano Takashi, Miura Shinji, Ezaki Osamu

Abstract excerpt

Acyl-CoA:diacylglycerol acyltransferases (DGATs) catalyze the last step in triglyceride (TG) synthesis. The genes for two DGAT enzymes, DGAT1 and DGAT2, have been identified. To examine the roles of liver DGAT1 and DGAT2 in TG synthesis and very low density lipoprotein (VLDL) secretion, liver DGAT1- and DGAT2-overexpressing mice were created by adenovirus-mediated gene transfection. DGAT1-overexpressing mice had...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15797871
DOI: 10.1074/jbc.M412989200

Genes

DGAT1
DGAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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