Article
The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate.
Molecular biology of the cell - 1 Feb 2020
Jones Ramon D, Enam Charisma, Ibarra Rebeca, Borror Heather R, Mostoller Kaitlyn E, Fredrickson Eric K, Lin JiaBei, Chuang Edward, March Zachary, Shorter James, Ravid Tommer, Kleiger Gary, Gardner Richard G
Abstract excerpt
Protein misfolding is a recurring phenomenon that cells must manage; otherwise misfolded proteins can aggregate and become toxic should they persist. To counter this burden, cells have evolved protein quality control (PQC) mechanisms that manage misfolded proteins. Two classes of systems that function in PQC are chaperones that aid in protein folding and ubiquitin-protein ligases that ubiquitinate misfolded...
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