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Article

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

The Journal of biological chemistry - 21 Jun 2013

Guerriero Christopher J, Weiberth Kurt F, Brodsky Jeffrey L

Abstract excerpt

Accumulation of misfolded proteins in cellular compartments can result in stress-induced cell death. In the endoplasmic reticulum (ER), ER-associated degradation clears aberrant proteins from the secretory pathway. In the cytoplasm and nucleus, this job is left to the cytoplasmic quality control (CytoQC) machinery. Both processes utilize chaperones and the ubiquitin-proteasome system to aid in protein...

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Identifiers

PMID: 23653356
DOI: 10.1074/jbc.M113.475905
PMCID: PMC3689992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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