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Article

Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling.

Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2005

DeYulia Garrett J, Cárcamo Juan M, Bórquez-Ojeda Oriana, Shelton Christopher C, Golde David W

Abstract excerpt

Reactive oxygen species (ROS) are key components of postreceptor intracellular signaling pathways; however, the role of ROS in signal initiation is uncertain. We discovered that receptor-ligand interaction caused the generation of hydrogen peroxide (H2O2). Using members of the hematopoietin receptor superfamily, as well as EGF receptor, we show that H2O2 is generated by specific receptor-ligand interaction in...

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Identifiers

PMID: 15795385
DOI: 10.1073/pnas.0501154102
PMCID: PMC556007

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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