Article
Stimulated human leukocytes cause activating mutations in the K-ras protooncogene.
Oncogene - 12 Jun 1997
Jackson J H, Vollenweider M, Hill J, Rodriguez H, Schwabacher A W, Mitra G, Kuo C Y
Abstract excerpt
Human tissues which are chronically infiltrated with inflammatory leukocytes are more likely to develop malignancies than non-inflamed tissues, however the mechanism(s) by which leukocytes contribute to carcinogenesis is unknown. Stimulated human leukocytes release superoxide anion and hydrogen peroxide which, in the presence of iron, can be converted into the potent oxidant, hydroxyl radical (.OH). Previous...
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