Article
H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells.
The Journal of biological chemistry - 4 Dec 1998
Lakshminarayanan V, Drab-Weiss E A, Roebuck K A
Abstract excerpt
We previously demonstrated that tumor necrosis factor-alpha (TNFalpha) and H2O2 differentially regulate interleukin-8 (IL-8) and intercellular adhesion molecule (ICAM-1) gene expression in endothelial and epithelial cells. H2O2 induced IL-8 expression in the A549 and BEAS-2B epithelial cell lines...
Topics
- Base Sequence
- DNA Primers
- Endothelium, Vascular
- Epithelial Cells
- Humans
- Hydrogen Peroxide
- Interleukin-8
- Mutation
- NF-kappa B
- Oxidation-Reduction
- Promoter Regions, Genetic
- Protein Binding
- RNA, Messenger
- Sulfhydryl Compounds
- Transcription Factor AP-1
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha