Article
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes.
The FEBS journal - 1 Apr 2005
Grall Franck T, Prall Wolf C, Wei Wanjiang, Gu Xuesong, Cho Je-Yoel, Choy Bob K, Zerbini Luiz F, Inan Mehmet S, Goldring Steven R, Gravallese Ellen M, Goldring Mary B, Oettgen Peter, Libermann Towia A
Abstract excerpt
Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX-2 production is triggered by exposure to various cytokines and to bacterial endotoxins. We present here a novel role for the Ets transcription factor ESE-1 in regulating the COX-2 gene in response to endotoxin and other pro-inflammatory stimuli. We report that the induction of COX-2 expression by...
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