Article
Overlapping CRE and E-box promoter elements can independently regulate COX-2 gene transcription in macrophages.
FEBS letters - 11 May 2001
Mestre J R, Rivadeneira D E, Mackrell P J, Duff M, Stapleton P P, Mack-Strong V, Maddali S, Smyth G P, Tanabe T, Daly J M
Abstract excerpt
Macrophage cyclooxygenase-2 (COX-2) transcription is mediated through the collaboration of different promoter elements. Here, the role of an overlapping cyclic AMP responsive element (CRE)/E-box was investigated. Nuclear proteins bound both the CRE and E-box, which synergized with other promoter elements to induce COX-2 transcription. Endotoxin induced binding of nuclear proteins to the CRE and E-box and each...
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