Article
ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.
The Journal of biological chemistry - 2 Feb 2001
Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella M A, Libermann T A, Oettgen P
Abstract excerpt
Inflammation is a hallmark of several vascular diseases. The nuclear factor kappaB (NF-kappaB) transcription factors are dimeric proteins involved in the activation of a large number of genes in response to inflammatory stimuli. We report the involvement of a novel member of the ETS transcription factor, ESE-1, in mediating vascular inflammation. ESE-1 is induced in response to inflammatory cytokines and...
Topics
- Binding Sites
- Calcium-Binding Proteins
- Cells, Cultured
- Cytokines
- DNA-Binding Proteins
- Humans
- Inflammation
- Inflammation Mediators
- Membrane Glycoproteins
- Mutation
- NF-kappa B
- Nerve Tissue Proteins
- Nitric Oxide Synthase