Article
A novel transgenic chimaeric mouse system for the rapid functional evaluation of genes encoding secreted proteins.
Nucleic acids research - 24 May 2005
Kakitani Makoto, Oshima Takeshi, Horikoshi Kaori, Yoshitome Tetsuo, Ueda Akiko, Kajikawa Miwa, Iba Yumi, Ozone Yoshinao, Ijima Yuki, Yoshino Tohko, Itoh Mikiko, Seki Sachiko, Aoki Ayako, Ishihara Toshie, Shionoya Michiyo, Makino Utako, Kitada Rina, Ohguma Atsuko, Ohta Takami, Yoshida Yoshimasa, Kudoh Hiroe, Hanaoka Kazunori, Sibuya Kazunori, Ishida Isao, Kakeda Minoru, Yagi Mikio, Yoneya Takashi, Tomizuka Kazuma
Abstract excerpt
A major challenge of the post-genomic era is the functional characterization of anonymous open reading frames (ORFs) identified by the Human Genome Project. In this context, there is a strong requirement for the development of technologies that enhance our ability to analyze gene functions at the level of the whole organism. Here, we describe a rapid and efficient procedure to generate transgenic chimaeric mice...
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