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Article

Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism.

Obesity research - 1 May 2005

Ukkola Olavi, Rankinen Tuomo, Lakka Timo, Leon Arthur S, Skinner James S, Wilmore Jack H, Rao D C, Kesäniemi Y A, Bouchard Claude

Abstract excerpt

Protein tyrosine phosphatase 1B (PTPN1) affects the regulation of insulin signaling and energy metabolism. We studied whether polymorphisms in the PTPN1 gene impact body fat distribution in the HERITAGE Family Study cohort in 502 white and 276 black subjects. Insulin sensitivity index, glucose disappearance index, acute insulin response to glucose (AIR(glucose)), and the disposition index (DI) were obtained from...

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Source

Identifiers

PMID: 15919835
DOI: 10.1038/oby.2005.95

Genes

PTPN1

Variants

Provenance

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Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism.PMID 15919835Read ↗

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Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population.Semantic proximity Read ↗

Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.Semantic proximity Read ↗

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans.Semantic proximity Read ↗

Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes.Semantic proximity Read ↗

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.Semantic proximity Read ↗

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.Semantic proximity Read ↗

Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects.Semantic proximity Read ↗

Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study.Semantic proximity Read ↗

Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.Semantic proximity Read ↗

Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes.Semantic proximity Read ↗

PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol.Semantic proximity Read ↗

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