Article
Infrequent RAS mutation is not associated with specific histological phenotype in gliomas.
BMC cancer - 15 Sept 2021
Makino Yasuhide, Arakawa Yoshiki, Yoshioka Ema, Shofuda Tomoko, Minamiguchi Sachiko, Kawauchi Takeshi, Tanji Masahiro, Kanematsu Daisuke, Nonaka Masahiro, Okita Yoshiko, Kodama Yoshinori, Mano Masayuki, Hirose Takanori, Mineharu Yohei, Miyamoto Susumu, Kanemura Yonehiro
Abstract excerpt
BACKGROUND: Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS family genes activate MAPK through activation of RAF and PI3K to promote cell proliferation. RAS mutations are a well-known driver of mutation in many types of cancers, but knowledge of...
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