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Article

A threshold requirement for Gbx2 levels in hindbrain development.

Development (Cambridge, England) - 1 May 2006

Waters Samuel T, Lewandoski Mark

Abstract excerpt

Gbx2 is a homeobox gene that plays a crucial role in positioning the mid/hindbrain organizer (isthmus), which regulates midbrain and cerebellar development primarily through the secreted factor FGF8. In Gbx2 null homozygotes, rhombomeres (r) 1-3 fail to develop and the isthmic expression of Fgf8 is reduced and disorganized. These mutants fail to form a cerebellum, as it is derived from r1. Here, we analyze mice...

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Identifiers

PMID: 16651541
DOI: 10.1242/dev.02364

Genes

FGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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