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Article

Engineering and functional immobilization of opioid receptors.

Protein engineering, design & selection : PEDS - 1 Mar 2005

Ott David, Neldner Yvonne, Cèbe Régis, Dodevski Igor, Plückthun Andreas

Abstract excerpt

Opioid receptors, like many G protein-coupled receptors (GPCRs), are notoriously unstable in detergents. We have now developed a more stable variant of the mu-opioid receptor (MOR) and also a method for the immobilization of solubilized, functional opioid receptors on a solid phase (magnetic beads). Starting with the intrinsically more stable kappa-opioid receptor (KOR), we optimized the conditions (i.e....

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Identifiers

PMID: 15790572
DOI: 10.1093/protein/gzi012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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