Article
Nanodelivery of a functional membrane receptor to manipulate cellular phenotype.
Scientific reports - 23 Feb 2018
Patriarchi Tommaso, Shen Ao, He Wei, Baikoghli Mo, Cheng R Holland, Xiang Yang K, Coleman Matthew A, Tian Lin
Abstract excerpt
Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically challenging and produce unwanted side effects. Here we develop and validate a nanodelivery approach to transfer in vitro synthesized, functional membrane receptors into the...
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