Article
Mutator activity and specificity of Escherichia coli dnaQ49 allele--effect of umuDC products.
Mutation research - 2 May 2005
Nowosielska Anetta, Wrzesiński Michał, Nieminuszczy Jadwiga, Janion Celina, Grzesiuk Elzbieta
Abstract excerpt
The high fidelity of DNA replication in Escherichia coli is ensured by the alpha (DnaE) and epsilon (DnaQ) subunits of DNA polymerase providing insertion fidelity, 3'-->5' exonuclease proofreading activity, and by the dam-directed mismatch repair system. dnaQ49 is a recessive allele that confers a temperature-sensitive proofreading phenotype resulting in a high rate of spontaneous mutations and chronic induction...
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