Article
Molecular evolution of the lysine decarboxylase-defective phenotype in Shigella sonnei.
International journal of medical microbiology : IJMM - 1 Mar 2005
Casalino Mariassunta, Latella Maria Carmela, Prosseda Gianni, Ceccarini Paolo, Grimont Francine, Colonna Bianca
Abstract excerpt
Shigella, the etiological agent of the bacillary dysentery, belongs to the extremely diverse species of Escherichia coli. In the evolutionary route of Shigella from commensal E. coli ancestors towards a pathogenic lifestyle, the critical events have been the acquisition of the pINV plasmid, through horizontal transfer and the inactivation of pre-existing genes. These so-called pathoadaptive mutations affect the...
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