Article
The two-faced role of cad genes in the virulence of pathogenic Escherichia coli.
Research in microbiology - 1 Jan 2000
Prosseda Gianni, Carmela Latella Maria, Barbagallo Marialuisa, Nicoletti Mauro, Al Kassas Rasha, Casalino Mariassunta, Colonna Bianca
Abstract excerpt
In enterobacteria, acid stress induces expression of the cad system which is involved in maintaining intracellular pH at levels compatible with cell survival. Despite its crucial role, the cad operon is silenced in Shigella and in other pathogenic Escherichia coli. In the present review, we will address the question of why and how the cad locus has been sacrificed for the sake of optimal expression of virulence...
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